Two sample MR report
SH3BGRL3_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0139109 | 0.1854609 | 0.9470363 |
| Weighted median | 4 | -0.0844488 | 0.0201513 | 0.0000278 |
| Inverse variance weighted | 4 | -0.0830394 | 0.0164311 | 0.0000004 |
| Simple mode | 4 | -0.0895811 | 0.0265110 | 0.0431225 |
| Weighted mode | 4 | -0.0890586 | 0.0239946 | 0.0340037 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1311235 | 2 | 0.9365412 |
| Inverse variance weighted | 0.4065568 | 3 | 0.9388847 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0437053 | 0.0832771 | 0.6520826 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.49e-05 | 0 | TRUE | 0.5309391 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
